Table 2.
Study eye differences in thickness at the level of photoreceptor layers (in z-score units) at three contour-lines at month 12 (modified intention-to-treat [mITT] analysis).
| Layer | Contrast | 0.43° | 2.58° | 5.16° | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Estimate | 95% CI | P-value* | Estimate | 95% CI | P-value* | Estimate | 95% CI | P-value* | ||
| ONL | (APL-2 Monthly)-Sham pooled | 0.1 | [− 0.03, 0.24] | 0.16 | 0.26 | [0.14, 0.38] | < 0.001 | 0.29 | [0.16, 0.42] | < 0.001 |
| ONL | (APL-2 EOM)-Sham pooled | 0.12 | [− 0.01, 0.26] | 0.09 | 0.16 | [0.04, 0.29] | 0.006 | 0.26 | [0.13, 0.4] | < 0.001 |
| ONL | (APL-2 Monthly)-(APL-2 EOM) | − 0.02 | [− 0.15, 0.12] | 0.95 | 0.09 | [− 0.03, 0.22] | 0.17 | 0.02 | [− 0.11, 0.16] | 0.92 |
| IS | (APL-2 Monthly)-Sham pooled | 0.68 | [0.09, 1.28] | 0.02 | 0.48 | [0.21, 0.75] | < 0.001 | 0.42 | [0.21, 0.62] | < 0.001 |
| IS | (APL-2 EOM)-Sham pooled | 1.09 | [0.48, 1.71] | < 0.001 | 0.4 | [0.12, 0.68] | 0.002 | 0.34 | [0.12, 0.55] | < 0.001 |
| IS | (APL-2 Monthly)-(APL-2 EOM) | − 0.41 | [− 1.02, 0.2] | 0.26 | 0.08 | [− 0.2, 0.36] | 0.78 | 0.08 | [− 0.13, 0.29] | 0.64 |
| OS | (APL-2 Monthly)-Sham pooled | − 0.09 | [− 0.38, 0.19] | 0.72 | 0.18 | [− 0.12, 0.48] | 0.33 | 0.29 | [− 0.01, 0.58] | 0.06 |
| OS | (APL-2 EOM)-Sham pooled | 0.05 | [− 0.24, 0.35] | 0.9 | 0.52 | [0.21, 0.83] | < 0.001 | 0.3 | [− 0.01, 0.6] | 0.06 |
| OS | (APL-2 Monthly)-(APL-2 EOM) | − 0.15 | [− 0.44, 0.14] | 0.45 | − 0.34 | [− 0.64, − 0.03] | 0.03 | − 0.01 | [− 0.31, 0.3] | 1 |
*P-values were obtained using Kenward-Roger approximation to estimate the denominator degrees of freedom. P-values were adjusted within each model (i.e., combination of layer and contour-line) using the Tukey method for comparing a family of 3 estimates.