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. 2022 Oct 25;12:17835. doi: 10.1038/s41598-022-21850-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cellular treatment affected the differential expression of pro/anti-inflammatory cytokine genes in CNS experimental groups. Quantitative RT- PCR data from spinal cord homogenates showed significant downregulation of pro-inflammatory cytokines (IL- 17, IFN -γ , and TNF -α) and upregulation of anti-inflammatory cytokines (IL-4 and IL-10) in the treated groups compared to an untreated group that was very prominent in IFN-β/LIF-hADSCs group. (The results are shown as mean ± SEM of three animals, *P < 0.05, **P < 0.01, ***P < 0.001 (One-way ANOVA).IL-4:(F3,8 = 17.761, P = 0.001), IL-10:(F3,8 = 33.937, P = 0.000) IL-17:(F3,8 = 4.250, P = 0.045), IFN –γ:(F3,8 = 197.041, P = 0.000), TNF –α:(F3,8 = 4.570, P = 0.038).