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. 2022 Oct 25;12:17908. doi: 10.1038/s41598-022-22963-x

Figure 3.

Figure 3

Differential effect of UB-ALT-EV treatment over memantine treatment on gene expression of pro-inflammatory and anti-inflammatory microglial markers in 5XFAD mice. Representative Western Blot and quantification for NF-κB (a). Values in bar graphs are adjusted to 100% for protein levels of the wild type (WT). Representative gene expression for Il-6 (b), Il-1β (c), Ifn-γ (d), Tnf-α (e), Ccl2 (f), Ccl3 (g), Ccl12 (h), Ym1 (i), Arg1 (j), Bdnf (k) Ngf (l), Vgf (m) and iNOS (n). Values are the mean ± Standard error of the mean (SEM); (n = 3 for WT and Control groups and n = 4 for Mem and UB-ALT-EV groups. For WT vs. 5XFAD Control groups data was analyzed using a two-tail Student’s t-test, and for 5XFAD groups a standard one-way ANOVA followed by Tukey post-hoc analysis was performed. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 for WT vs. Control. #p < 0.05; ###p < 0.001 for Mem or UB-ALT-EV vs. Control.