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. 2022 Aug 19;127(9):1680–1690. doi: 10.1038/s41416-022-01915-2

Fig. 4. Summary of the genetic and clinical profiles of patients with somatic variants in the 27 analysed genes.

Fig. 4

a Summary of the genetic and clinical profiles of patients with somatic mutations in the 27 analysed genes. b Kaplan–Meier curve showing time to castration resistance from initiation of androgen deprivation therapy (ADT) for patients with or without somatic mutations in HBOC-associated genes (BRCA1, BRCA2, PALB2 or ATM). Group differences were tested by performing log-rank tests. c Kaplan–Meier curve showing overall survival from the time of diagnosis for patients with and without somatic mutations in HBOC-associated genes.