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. 2022 Oct 25;13:6088. doi: 10.1038/s41467-022-33203-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Mean ± SEM number of arrhythmias per hour of ECG monitoring in males and both sexes (inset). b Representative VPBs (arrows) in an E-Menthol-exposed male. c Mean ± SEM number of high-grade SVB events per hour of ECG monitoring in males (smaller values in right inset) and females (left inset). d Representative high-grade SVBs, resembling atrioventricular block with non-conducted P waves (upper waveform, arrow), sinoatrial block lacking P waves (lower waveform); similar block events with noise preventing confirmation of P or its absence are not shown. Significance determined by two-sided P < 0.05 (vs. Air: star) in generalized estimating equations. For box and whisker plots, upper and lower box bounds indicate 25th and 75th percentile, with horizontal mid-line denoting median, “+” indicating mean, and circles indicating individual values (for males, n = 8 for Air, PG, PG:VG, VG, Acrolein [Acro], MCS 1R5F; n = 7 for E-Menth; n = 6 for MCS 3R4F; n = 4 for E-Tobacco; for females, n = 4/exposure). Source data, including all p values, are provided as a Source Data file.