Table 3.
Summary of plasma curcumin concentration in studies examining the effect of curcumin intake on exercise-induced muscle damage (EIMD)
| Author and year | Population | Duration | Curcumin supplement | Dosage | Plasma curcumin concentration | Sample hydrolysis |
|---|---|---|---|---|---|---|
| Takahashi et al., 2013 [25] |
26 males (26.8 ± 2.0 years) (recreationally active) |
1 day | Theracurmin | Control | Plasma curcumin concentrations in the double curcumin supplementation trial 2 h after exercise were significantly higher than those in the single curcumin supplementation trial | Hydrolysis |
|
90 mg/day 2 h before exercise | ||||||
|
180 mg/day 2 h before and immediately after exercise | ||||||
| Tanabe et al., 2018 [22] |
10 males (28.5 ± 3.4 years) (untrained) |
7 days | Theracurmin |
Experiment 1—180 mg (90 mg twice a day—at breakfast and dinner) consumed for 7 days before exercise |
Plasma curcumin concentrations significantly decreased from baseline (38.8 ± 17.8 ng mL−1) to 1, 3, 5, and 7 days after exercise (10.2 ± 5.4, 5.0 ± 2.7, 0.1 ± 0.4, and 0.1 ± 0.2 ng mL−1, respectively) | No mention of the process used |
|
10 males (29.0 ± 3.9 years) (untrained) |
Experiment 2—180 mg (90 mg twice a day—at breakfast and dinner) Consumed for 7 days after exercise |
Plasma curcumin significantly increased from baseline (5.3 ± 6.1 ng mL−1) to 1 day (50.6 ± 25.6 ng mL−1), and then maintained a high plasma curcumin concentration through 3, 5, and 7 days after exercise (58.5 ± 37.1, 42.2 ± 46.0, and 41.1 ± 29.2 ng mL−1, respectively) | ||||
| Tanabe et al., 2019 [23] |
8 males (28.0 ± 3.2 years) (untrained) |
7 days |
Theracurmin CR-033P |
Control | – | Hydrolysis |
|
8 males (28.8 ± 3.6 years) (untrained) |
PRE—180 mg (90 mg twice a day—at breakfast and dinner) Consumed for 7 days before exercise |
At baseline and at 1–3 d after exercise, the plasma curcumin concentration of the PRE group was significantly higher than that in the control and POST groups | ||||
|
8 males (29.8 ± 3.4 years) (untrained) |
POST—180 mg (90 mg twice a day—at breakfast and dinner) Consumed for 4 days after exercise |
At 1–4 d after exercise, the plasma curcumin concentration of the POST group was significantly higher than that of the control and PRE groups | ||||
| Tanabe et al., 2015 [53] |
14 males (23.5 ± 2.3 years) (UNTRAINED) |
Single dose | Theracurmin |
300 mg 150 mg—1 h before exercise 150 mg—12 h after exercise |
Plasma curcumin concentration increased from baseline (0.04 ± 0.07 ng/mL) to 127.7 ± 144.6, 85.7 ± 51.6, 8.6 ± 5.5, 2.2 ± 1.4 and 0.9 ± 0.6 ng/mL at 0, 24, 48, 72 and 96 h after exercise, respectively | No mention of the process used |
| Sciberras et al., 2015 [52] |
11 males (35.5 ± 5.7 years) (trained) |
4 days | Meriva® | 500 mg with midday meal for 3 days and 500 mg just before exercise | Mean ± SD (range) curcumin concentration obtained was 79.7 ± 26.3 ng/ml (50.7 ng/mL to 125.5 ng/mL) | Hydrolysis |