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. 2022 Oct 19;5:1976–1984. doi: 10.1016/j.crfs.2022.10.021

Fig. 4.

Fig. 4

Effects of acetate on the mRNA expression of hepatic and ileal related enzymes and transporters that involve in cholesterol and BAs metabolism. The expression of genes associated with BAs synthesis (CYP7A1, CYP8B1 and CYP27A1), negative feedback regulation of BAs synthesis (FXR, SHP and FGFR4), and cholesterol synthesis and secretion (HMGR and ABCG5) in the hepatic tissue (a–h). The expression of genes associated with negative feedback regulation of BAs synthesis (FXR and FGF15), BAs reabsorption (ASBT) and cholesterol secretion (ABCG5) in the ileum(i-l). * Compared to the C group; # compared to the HFD group. p < 0.05 (*/#), p < 0.01 (**/##), p < 0.001 (***/###).