Table 1.
Number of trials and survival rates of in utero cell transplantation. For mdx mice and DMD rats, analysis was performed at 4 weeks of age. No GFP-positive cells or GFP mRNA were detected by immunofluorescence staining or RT-qPCR of muscle. Preliminary placental transplantation experiments on Wistar rats resulted in death of all fetuses.
| Species | Method | Cell type | Number of fetuses (mothers) | Number of births | Survival rate(%) |
|---|---|---|---|---|---|
| mdx mouse | ip | myoblast | 22(3) | 9 | 41 |
| ASC | 21(3) | 1 | 4.8 | ||
| pl | myoblast | 7(1) | 6 | 86 | |
| ASC | 8(1) | 0 | 0 | ||
| DMD Rat | ip | ASC | 41(3) | 17 | 41 |
| Wistar Rat | pl | ASC | 40(3) | ||
ip: intraperitoneal administration, pl: placental administration, ASC: adipose-derived stem cell.