Table 2.

Prediction of mutations’ deleterious effects

SNP	PredictSNP	MAPP	PhD-SNP	PolyPhen-1	PolyPhen-2	SIFT	SNAP	nsSNP-Analyzer	PANTHER
V136F	D	D	D	D	D	D	D	D	D
Q458K	D	D	D	D	D	D	D	D	-
V466A	D	D	D	N	N	D	D	D	N
A467T	D	D	D	D	D	D	D	D	N
H471N	D	N	D	N	D	D	D	N	N
H471Y	D	D	D	D	D	D	D	D	D
H471L	D	D	D	D	D	D	D	D	D
I517M	D	D	D	D	D	D	D	D	D

N refers to the neutral/stable effect of variant, while D refers to its deleterious/nonstable effect