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. 2022 Oct 25;20:146. doi: 10.1186/s43141-022-00428-y

Table 3.

Prediction of changes on the protein stability

SNP I-Mutant3 MUpro
ΔΔG Prediction ΔΔG Prediction
V136F − 1.37 DECREASE − 0.68 Decrease
Q458K − 0.56 DECREASE − 1.62 Decrease
V466A − 1.51 DECREASE − 0.93 Decrease
A467T − 0.84 DECREASE − 0.9 Decrease
H471N − 0.62 DECREASE − 0.82 Decrease
H471Y 0.27 INCREASE − 0.36 Decrease
H471L 0.52 INCREASE − 0.05 Decrease
I517M − 1.68 DECREASE − 0.68 Decrease