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. 2022 Sep 15;6(6):859–870. doi: 10.1007/s41669-022-00363-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Model structure. Rounded rectangles on the top row represent health states and rounded rectangles on the bottom row represent events that patients could experience at any time. Patients who reached an EDSS score of ≥ 7 while on treatment would discontinue treatment and receive BSC. BSC best supportive care, EDSS expanded disability status scale