Table 7.
Summary of (dis)utilities
| (Dis)utilities (SE) | References | |
|---|---|---|
| Patient health state utility | ||
| EDSS | ||
| 0 | 0.86 (0.00) | Guertin et al.a [40] |
| 1 | 0.73 (0.15) | Tappenden et al.b [41] |
| 2 | 0.62 (0.12) | Tappenden et al.b [41] |
| 3 | 0.54 (0.11) | Tappenden et al.b [41] |
| 4 | 0.47 (0.09) | Tappenden et al.b [41] |
| 5 | 0.40 (0.08) | Tappenden et al.b [41] |
| 6 | 0.30 (0.06) | Tappenden et al.b [41] |
| 7 | 0.17 (0.03) | Tappenden et al.b [41] |
| 8 | − 0.03 (− 0.01) | Tappenden et al.b [41] |
| 9 | − 0.31 (− 0.06) | Tappenden et al.b [41] |
| Caregiver disutility | ||
| EDSS | ||
| 0 | 0.00 (0.11) | Acaster et al. [42] |
| 1 | 0.00 (0.11) | Acaster et al. [42] |
| 2 | 0.04 (0.11) | Acaster et al. [42] |
| 3 | 0.04(0.11) | Acaster et al. [42] |
| 4 | 0.14 (0.12) | Acaster et al. [42] |
| 5 | 0.16 (0.11) | Acaster et al. [42] |
| 6 | 0.17 (0.11) | Acaster et al. [42] |
| 7 | 0.03 (0.08) | Acaster et al. [42] |
| 8 | 0.09 (0.15) | Acaster et al. [42] |
| 9 | 0.09 (0.15) | Acaster et al. [42] |
| Relapse disutility | ||
| Mild | 0.09 (0.01) | Prosser et al. [43] |
| Moderate | 0.09 (0.01) | Prosser et al. [43] |
| Severe | 0.30 (0.03) | Prosser et al. [43] |
| AE disutility | ||
| Non-serious | 0.00 (0.00) | Assumptionc |
| Serious | 0.04 (0.01) | Assumptiond |
aGiven that the modeled data for EDSS 0 resulted in a utility value that was not clinically plausible, the mean utility value for EDSS 0 was based on normative utility data for the Canadian population
bMean utility values for EDSS health states 1–9 were obtained from the functional form modeled Health Utilities Index Mark 3 (HUI3) utility data in Fig. 1 of Tappenden et al. [41] using PlotDigitizer software
cAssumption that a non-serious AE disutility of 0.25 was experienced for 7 days
dAssumption that a serious AE disutility of 0.5 was applied for 1 month
AE adverse event, EDSS expanded disability status scale, SE standard error