Table 2.
Further study characteristics and standardised incidence ratio estimates.
| Author and publication year | Total person-years | Follow-up time strata (since first breast cancer diagnosis) | Age strata (at first breast cancer diagnosis) | Specific second primary cancers for which standardised incidence ratios were reported | Number with first breast cancer/number with second primary cancer | Standardised incidence ratio (95% confidence interval) for combined risk of non-breast second primary cancers |
|---|---|---|---|---|---|---|
| AIRTUM Working Group, 2013 [6] | 9402 | 0–1 ma, 2–11 m, 12–59 m, 60–119 m, >120 m | 0–19, 20–29, 30–39, 40–49, 50–69, >70 | Bladder and urinary tract, bone, brain and central nervous system, colon, colon rectum, gallbladder, head and neck, Hodgkin lymphoma, Kaposi sarcoma, kidney and renal pelvis, larynx, leukaemias, liver, lung, lymphoid leukaemia, mesothylioma, multiple myeloma, myeloid leukaemia, non-Hodgkin lymphomas, oesophagus, oral cavity, other leukaemias, other sites, pancreas, pharynx, prostate, rectum, skin melanoma, soft tissue, stomach, testis, thyroid, urinary bladder, urinary tract | 1904/221 | 1.11 (0.97–1.27) |
| Chen, 2015 [3] |
Germany: unreported Sweden: unreported |
Germany: unreported Sweden: unreported |
Germany: unreported Sweden: unreported |
Germany: unreported Sweden: unreported |
Germany: unreported/104 Sweden: unreported/52 |
Germany: 1.1 (0.9–1.3) Sweden: 1.1 (0.8–1.5) |
| Dong, 2001 [9] | 3105 | 0–9 yb, 10–38 y | Unreported | Unreported | 457/50 | 1.22 (0.91–1.61)c |
| Hemminki, 2005 [5] | Unreported | <1 y, 1–9 y, >9 y |
<56, 56–65, 66–74, >75 |
Oral cavity and pharynx, stomach, small intestine, colorectal, colon, rectum, liver (both alone and including gallbladder and bile ducts), pancreas, larynx, lung, melanoma of skin, other neoplasm of skin, prostate, bladder, kidney, lymphohaematopoietic (all lymphomas combined, non-Hodgkins lymphoma, multiple myeloma, and leukaemias (lymphoid leukaemia, myeloid leukaemia)) | 3409/426 | 1.34 (1.22–1.47) |
| Hung, 2016 [7] | 2773 | 0–1 y, 1–5 y, >=4 y | 20–29, 30–39, 40–49, 50–59, 60–69, 70–79, >80 | Head and neck, oesophagus, stomach, colon and rectum and anus, liver and biliary tract, liver, lung and mediastinum, bone and soft tissue, skin, prostate, bladder, kidney, thyroid, haematologic malignancies, all others | 578/73 | 2.17 (1.70–2.73) |
| Jégu, 2014 [4] | 2282 | Unreported | Unreported | Unreported | Unreported/52 | 1.14 (0.85–1.50)c |
| Satram-Hoang, 2007 [8] | 8529 | <1 y, 1–5 y, >5 y | <60 y, 60–69 y, >69 y | Prostate, colorectal, lung and bronchus, bladder, melanoma, stomach | 1986/201 | 1.05 (0.91–1.20) |
| Sung, 2020 [12] | 10224 | Unreported | Unreported | Unreported | 1704/272 | 1.14 (1–1.3) |
aMonth/months.
bYear/years.
cConfidence interval generated using Byar’s approximation.