Table 2.
Combined effect of the DE clock genes CRY1, NR1D2 and PER3 in placenta on the risk of overall PE with firth logistic regression model for two independent datasets.
| Risk score* | N (%) | Non-PE, n (%) | PE, n (%) | ORPE vs. Non-PE (95% CI) | p |
|---|---|---|---|---|---|
| GSE75010-157 | |||||
| < Median | 78 (100.0) | 54 (69.2) | 24 (30.8) | Ref | |
| > Median | 79 (100.0) | 23 (29.1) | 56 (70.9) | 5.35 (2.70, 10.57) | < 0.0001 |
| GSE75010-173 | |||||
| < Median | 86 (100.0) | 65 (75.6) | 21 (24.4) | Ref | |
| > Median | 87 (100.0) | 31 (35.6) | 56 (64.4) | 5.46 (2.83, 10.54) | < 0.0001 |
*Risk score = CRY1 + (11-NR1D2) + (9-PER3).
Bold values denote statistical significance (p < 0.05).