Table 3.
Top 10 pathways correlated with CRY1, NR1D2 and PER3-based risk score in placenta (overall PE vs. overall non-PE) in two independent datasets (cut-off: p < 0.05 and FDR < 0.10).
| Risk score*-correlated pathway | GSE75010-157 | GSE75010-173 | ||||
|---|---|---|---|---|---|---|
| r (95% CI) | p | FDR | r (95% CI) | p | FDR | |
| Top 10 decreased pathways in overall PE: | ||||||
| REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1 | −0.57 (−0.67, −0.45) | < 0.0001 | 0.0002 | −0.36 (−0.49, −0.23) | < 0.0001 | 0.0009 |
| REACTOME_SIGNALING_BY_HEDGEHOG | −0.54 (−0.64, −0.42) | < 0.0001 | 0.0002 | −0.42 (−0.53, −0.29) | < 0.0001 | 0.0009 |
| REACTOME_NEGATIVE_REGULATION_OF_MET_ACTIVITY | −0.53 (−0.63, −0.40) | < 0.0001 | 0.0002 | −0.29 (−0.42, −0.14) | 0.0001 | 0.0009 |
| REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING | −0.51 (−0.62, −0.39) | < 0.0001 | 0.0002 | −0.32 (−0.45, −0.18) | < 0.0001 | 0.0009 |
| REACTOME_HEDGEHOG_ON_STATE | −0.50 (−0.61, −0.37) | < 0.0001 | 0.0002 | −0.38 (−0.50, −0.24) | < 0.0001 | 0.0009 |
| KEGG_BETA_ALANINE_METABOLISM | −0.50 (−0.61, −0.37) | < 0.0001 | 0.0002 | −0.33 (−0.46, −0.19) | < 0.0001 | 0.0009 |
| REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION | −0.50 (−0.60, −0.37) | < 0.0001 | 0.0002 | −0.27 (−0.40, −0.13) | 0.0003 | 0.0019 |
| REACTOME_PCP_CE_PATHWAY | −0.49 (−0.60, −0.37) | < 0.0001 | 0.0002 | −0.29 (−0.42, −0.15) | 0.0001 | 0.0009 |
| REACTOME_SIGNALING_BY_NOTCH4 | −0.49 (−0.60, −0.36) | < 0.0001 | 0.0002 | −0.30 (−0.43, −0.15) | < 0.0001 | 0.0009 |
| REACTOME_METALLOPROTEASE_DUBS | −0.49 (−0.60, −0.36) | < 0.0001 | 0.0002 | −0.25 (−0.38, −0.10) | 0.001 | 0.0047 |
| Top 10 increased pathways in overall PE: | ||||||
| KEGG_GALACTOSE_METABOLISM | 0.54 (0.42, 0.65) | < 0.0001 | 0.0002 | 0.39 (0.26, 0.51) | < 0.0001 | 0.0009 |
| PID_HIF1_TFPATHWAY | 0.52 (0.39, 0.62) | < 0.0001 | 0.0002 | 0.36 (0.22, 0.48) | < 0.0001 | 0.0009 |
| WP_TRANSCRIPTIONAL_CASCADE_REGULATING_ADIPOGENESIS | 0.50 (0.37, 0.61) | < 0.0001 | 0.0002 | 0.32 (0.18, 0.45) | < 0.0001 | 0.0009 |
| KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY | 0.49 (0.36, 0.60) | < 0.0001 | 0.0002 | 0.35 (0.22, 0.48) | < 0.0001 | 0.0009 |
| REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | 0.48 (0.35, 0.59) | < 0.0001 | 0.0002 | 0.23 (0.09, 0.37) | 0.0019 | 0.0078 |
| PID_P38_MKK3_6PATHWAY | 0.46 (0.32, 0.57) | < 0.0001 | 0.0002 | 0.24 (0.10, 0.38) | 0.0012 | 0.0054 |
| WP_CORI_CYCLE | 0.46 (0.33, 0.57) | < 0.0001 | 0.0002 | 0.38 (0.25, 0.50) | < 0.0001 | 0.0009 |
| PID_HIF2PATHWAY | 0.45 (0.32, 0.57) | < 0.0001 | 0.0002 | 0.30 (0.16, 0.43) | < 0.0001 | 0.0009 |
| KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY | 0.44 (0.31, 0.56) | < 0.0001 | 0.0002 | 0.30 (0.16, 0.43) | < 0.0001 | 0.0009 |
| REACTOME_ACTIVATION_OF_AMPK_DOWNSTREAM_OF_NMDARS | 0.44 (0.31, 0.56) | < 0.0001 | 0.0002 | 0.17 (0.02, 0.31) | 0.0234 | 0.0515 |
*Risk score = CRY1 + (11-NR1D2) + (9-PER3).