Table 5.
Top 10 pathways correlated with CRY1, NR1D2 and PER3-based risk score in placenta (PE without PTB vs. non-PE without PTB) in GSE75010-157 dataset. Cut-off: p < 0.05 and FDR < 0.10.
| Risk score*-correlated pathway | r | p | FDR |
|---|---|---|---|
| Top 10 decreased pathways in PE without PTB | |||
| REACTOME_INTRA_GOLGI_TRAFFIC | − 0.53 | < 0.0001 | 0.0007 |
| REACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS | − 0.47 | < 0.0001 | 0.0007 |
| KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT | − 0.44 | < 0.0001 | 0.0007 |
| BIOCARTA_IGF1MTOR_PATHWAY | − 0.40 | 0.0004 | 0.0019 |
| REACTOME_PEXOPHAGY | − 0.39 | 0.0005 | 0.0022 |
| WP_NANOPARTICLE_TRIGGERED_AUTOPHAGIC_CELL_DEATH | − 0.39 | 0.0006 | 0.0023 |
| REACTOME_RAB_REGULATION_OF_TRAFFICKING | − 0.35 | 0.0023 | 0.0068 |
| REACTOME_VXPX_CARGO_TARGETING_TO_CILIUM | − 0.34 | 0.003 | 0.0078 |
| REACTOME_TRANSLATION_OF_REPLICASE_AND_ASSEMBLY_OF_THE_REPLICATION_TRANSCRIPTION_COMPLEX | − 0.34 | 0.003 | 0.0078 |
| WP_AUTOPHAGY | − 0.32 | 0.0055 | 0.0126 |
| Top 10 increased pathways in PE without PTB | |||
| WP_CORI_CYCLE | 0.52 | < 0.0001 | 0.0007 |
| WP_GLYCOLYSIS_AND_GLUCONEOGENESIS | 0.50 | < 0.0001 | 0.0007 |
| BIOCARTA_ACH_PATHWAY | 0.46 | < 0.0001 | 0.0007 |
| WP_COMPUTATIONAL_MODEL_OF_AEROBIC_GLYCOLYSIS | 0.45 | < 0.0001 | 0.0007 |
| PID_HIF1_TFPATHWAY | 0.44 | < 0.0001 | 0.0007 |
| KEGG_ARACHIDONIC_ACID_METABOLISM | 0.44 | < 0.0001 | 0.0007 |
| WP_ASPIRIN_AND_MIRNAS | 0.42 | 0.0002 | 0.0012 |
| WP_PHOTODYNAMIC_THERAPYINDUCED_HIF1_SURVIVAL_SIGNALING | 0.40 | 0.0003 | 0.0016 |
| REACTOME_ACTIVATION_OF_AMPK_DOWNSTREAM_OF_NMDARS | 0.40 | 0.0003 | 0.0016 |
| REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE | 0.39 | 0.0006 | 0.0023 |
*Risk score = (10-CLOCK) + (11-NR1D2) + (9-PER3).