Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 12;13:960112. doi: 10.3389/fphar.2022.960112

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Han, Wen, Liu, Zhai, Li and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The main mechanisms of dibenzocyclooctene lignans against AD. (Dibenzocyclooctene lignans play a protective role in the nervous system through anti-inflammation, antioxidation and inhibition of neuronal apoptosis. Compounds 1–13 inhibited the activity of NO, compounds 11 and 13 inhibited the release of downstream inflammatory factors by regulating TLR-4-mediated NF-κB and MAPKs signaling pathways, MyD88/IKK/NF-κB and HSPA12B/PI3K/Akt signaling pathways. In addition, Compounds 10 and 12 up-regulated the expression of SOD and GSH, and inhibited MDA in brain tissue, while compounds 11 and 13 reduced the content of ROS to resist oxidative stress. Compound 13 also inhibited apoptosis by inhibiting JNK-mediated PDH inhibition.).