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. 2022 Sep 5;9(30):2201425. doi: 10.1002/advs.202201425

Figure 5.

Figure 5

The scavenging effects of PHTB(TA‐siRNA) hydrogels on a) the DPPH radical, b) ABTS∙+ radical, and c) H2O2 radical (***: p < 0.001, n = 5). d) The levels of subcutaneous ROS in rats treated with PHTB(TA‐siRNA) hydrogels. The subcutaneous‐ROS levels were detected using a dihydroethidium (DHE) fluorescent probe. The violet color indicates the content of intracellular ROS, and the blue color represents 4',6‐diamidino‐2‐phenylindole (DAPI)‐stained cell nucleus. The scale bar represents a 100 µm scale. e) Schematic diagram of the in vivo experiments to detect the scavenging of ROS by PHTB(TA‐siRNA) hydrogels. f) The levels of ROS in tissues that received different treatments (***: p < 0.001, n = 3). The green dashed line indicates the amount of ROS in normal skin tissues. g) The mechanism for the antioxidant properties of PHTB(TA‐siRNA) hydrogels.