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Supplementation of compounds for assessing lifespan changes of DNA repair-deficient mice. (A–D), Survival curves of Ercc1 Δ/− mice on resveratrol, metformin (A) or idebenone (D) supplemented diet and Xpg −/− mice treated with metformin, acarbose (B), aspirin or ibuprofen (C). Indicated values are Mean (±SD). Significant p values of log-rank survival test (B,D) are indicated.
