FIGURE 2.

The effect of mitochondrial modifiers and GlcNAc supplementation on the lifespan and onset of neurological phenotypes of Ercc1 ^Δ/− mice. (A–D), Comparison between Ercc1 ^Δ/− control mice and animals supplemented with sodium nitrite, DCA, or GlcNAc on water intake (A), food intake (B), bodyweight over time (C) and body weight as area under the curve (AUC) of measurements between 6–16 weeks (D). (E–G), Onset of neurological abnormalities; tremors (E) and imbalance (F), and survival (G) of the same animals. Indicated values are Mean (±SD). Significant p values of the Dunnet’s multiple comparison test (A,E,F) are indicated.