FIGURE 3.

The effect of nicotinamide adenine dinucleotide (NAD⁺) precursor ribosome supplementation on the lifespan and onset of neurological phenotypes of Ercc1 ^Δ/− mice. (A–C), Values of water intake (A), food intake (B) body weight changes over time (C) and body weight as area under the curve (AUC) (D) in control animals and animals receiving supplementation of two NAD⁺ precursors; NA and NR. (E–F), Onset of neurological abnormalities; tremors (E) and imbalance (F) with age of Ercc1 ^Δ/− control mice and mice receiving NR or NA. (G). Survival curve showing lifespan of the three groups. Indicated values are Mean (±SD). Significant p values of the Dunnet’s multiple comparison test (A) and log-rank survival test (F,G) are indicated.