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. 2022 Oct 12;12:1018034. doi: 10.3389/fonc.2022.1018034

Figure 1.

Figure 1

Identification of hotspot exonuclease domain mutations (EDMs) in the DNA polymerase ϵ gene (POLE) in endometrial cancer. A total of 35 nonsense/stop-gain, 39 frameshift, and 57 missense mutations were identified in 69/138 (50%) endometrial tumor samples from patients. Among these mutations, there were 49 POLE EDMs, comprising 1 nonsense/stop-gain mutation and 48 missense mutations, in 32/138 (23.2%) samples. (A) Patients were divided into EDM (n = 32), non-EDM (n = 37), and non-mutation (n = 69) groups. Kaplan-Meier analysis was performed to evaluate the association of POLE EDMs with progression free survival (PFS) and overall survival (OS). Blue line: patients with POLE EDM tumors; green line: patients with non-EDM tumors; orange line: patients with non-mutation tumors. (B) Prediction of deleterious EDMs. Pink dot: stop mutations; gray dot: deleterious mutations. (C) Modelling of the exonuclease domain mutations in POLE. Gray, 9–14 exons, 268–471 residues; pink, unrepeated deleterious mutations; red, recurrent deleterious mutations; yellow, stop mutations.