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. 2022 Oct 12;12:1018034. doi: 10.3389/fonc.2022.1018034

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Copyright © 2022 Tian, Ji, Wang, Meng, Bi, Ren, Shan, Yang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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POLE EDMs induced G0/G1 cell cycle arrest in endometrial cancer cells. HEC-1A cells were transiently transfected with wildtype POLE or P286R, R375Q, V411L, or P452L variant. (A) Flow cytometry analysis was conducted at 48 h after transfection to analyze the cell cycle. (B) Western blot analysis was carried out at 48 h after transfection to measure the protein levels of Cyclin A, clyclin B, cyclin B1, cyclin D1, CDK4, CDK6, P16, and P21. β-actin was used as an internal reference. Data are expressed as the mean ± SD.