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POLE EDM upregulated the expression of DNA mismatch repair genes. The stable POLE-knockdown HEK293T cells were transiently transfected with lentiviral vectors expressing wildtype POLE, POLE variants, or negative control. qRT-PCR (A, B) and Western blot analysis (C) were performed to measure mRNA and protein levels of POLE, MLH1, and MSH2. **P<0.01, ***P<0.001.
