Fig. 6.
Smaller size and altered gait in Col12a1Δten/Δten mice. (A) Representative gross images showing that Col12a1Δten/Δten mice are smaller than control Col12a1+/+ and heterozygous Col12a1+/Δten mice, with no obvious body size difference between control and heterozygous mice. All mice are male litter mates at 60 days. (B) Representative gait analysis showed shorter stride length in Col12a1Δten/Δten mice compared to wild type controls. However, all mice walk with regular, even steps, and there is no obvious change in the width of toe spread. The arrowed vertical lines indicate the stride lengths from the 3rd toe to adjacent 3rd toe of the same hind foot. Male 60 day mice. (C) Quantitative presentation of the stride length data from (B). There was a significant decrease in stride length in Col12a1Δten/Δten mice compared to heterozygous and wild type mice. There was no difference in the latter two groups. (*p < 0.05).