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. 2022 Jun 22;28(4):827–840. doi: 10.3350/cmh.2022.0068

Figure 7.

Figure 7.

Auranofin reduced intrahepatic adipogenesis and fibrosis in WD-induced NASH model mice. (A) The experimental schematic in WD fed NASH model mice. (B) H&E, Sirius red, and Oil-red O staining image in NASH model liver sample (×200). Data quantified based on (C) Oil-red O staining images and (D) Sirius red staining images. (E) Quantitative comparison of mRNA levels of fibrosis and lipogenesis markers in liver samples from NASH model mice. (F) Quantification of mRNA levels of NRF2 and its downstream, an antioxidant marker (vehicle, n=10; AR 3 mg, n=10; and AR 10 mg, n=10). WD, western diet; H&E, hematoxylin and eosin; TGF, transforming growth factor; COL1A1, collagen type 1 alpha 1 chain; NRF2, nuclear erythroid 2-related factor 2; NASH, non-alcoholic steatohepatitis. *P<0.05. **P<0.01. ***P<0.001. ****P<0.0001.