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. 2022 Oct 12;10:1014543. doi: 10.3389/fbioe.2022.1014543

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Copyright © 2022 Yi, Liu, Xie, An, Li, Wang and Chai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic presentation of the mechanism of nanocomposite hydrogel applied in the treatment of rheumatoid arthritis. CCPA and TP@HSA NPs formed the acupoint nanocomposite hydrogel, which can simulate acupuncture to relieve pain through the stimulation of A1R, and realize the targeted deliver TP to suppress inflammation by regulating the expression level of inflammatory factors and maintaining the immune balance. Reproduced with permission from Ren et al. Journal of Nanobiotechnology; Published by BioMed Central, 2021.