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. 2022 Oct 12;10:1006087. doi: 10.3389/fcell.2022.1006087

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Copyright © 2022 Moses, Mullen, Idowu, Maye, Jamin and Behringer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An Amhr2-containing BAC transgene rescues the block in Müllerian duct regression of Amhr2-null male mice. (A) Control male mouse possesses only male reproductive tract organs (epididymis, vas deferens) seen adjacent to the testis. (B) Amhr2 ^ΔE1-6/lacZ (null) male mouse carry one deletion allele and one lacZ knock-in/knockout allele. lacZ expression marks the uterus (open arrow) and oviduct (arrow) that forms in these mutants. (C) Male mouse with the Amhr2 BAC transgene (Tg ^BAC-Amhr2) on an Amhr2 ^ΔE1-6/lacZ background lacks lacZ expression because the block in Müllerian duct regression has been rescued preventing uterus/oviduct differentiation (Line 1, n = 2; Line 2, n = 2). Ov, oviduct; t, testis; ut, uterus.