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. 2022 Oct 12;13:983313. doi: 10.3389/fimmu.2022.983313

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Copyright © 2022 Mayer-Blackwell, Johnson, Potchen, Minot, Heptinstall, Seaton, Sawant, Shen, Tomaras, Fiore-Gartland and Kublin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microbiome associations with pre-vaccine gp41 IgG and Clustered co-abundant genes (CAGs) from fecal samples collected in HVTN 106. (A) Volcano plot of taxonomic features (the sum of all genes identified as part of any Clustered co-abundant genes (CAGs) assigned to a taxa, (B, C) Relative abundance of two of the most statistically significant taxa (x-axis) compared with pre-vaccine anti-gp41IgG (y-axis). (D) Fine scale mapping of genes identified in CAGs to genomes in the Blautia genus. Gene’s are mapped to genomes if they share 90% alignment identity at the amino acid level. The genes belonging to CAGs most consistently associated with anti-gp41 IgG pre vaccine have higher positive Wald statistics. Figure S3 shows the full tree, containing members of the genus lacking genes associated with anti-gp41 IgG.