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. 2022 Oct 12;10:972790. doi: 10.3389/fbioe.2022.972790

TABLE 7.

Some examples of surface modification techniques of different type of core particles.

Core particle Core particle size Core particle charge Coating material Surface modification technique Reference
Iron oxide NPs 5 nm −63 mV Tumor EM Electroporation Hood, Scott and Wickline, (2014)
Iron oxide NP 35–50 nm - Oleic acid Sonication Gupta et al. (2019)
Gold NP 45 nm - Tumor EM Freeze-thawing Sancho-Albero et al. (2019b)
Gold nanorod 46.5 ± 1.2 nm by 19.0 ± 0.7 nm +41.6 ± 0.6 mV Serum proteins Adsorption Yeo et al. (2017)
Magnetic nanoplates 52 nm - Polysaccharide Coprecipitation Stolyar et al. (2021)
Zeolitic imidazolate framework 91.4 nm +30.6 mV Tumor EM Microfluidics sonication Lv et al. (2021)
PCL NP 130 nm −57 mV Dextran Emulsion evaporation Lemarchand et al. (2006)
Albumin NP 138.7 ± 3.5 nm −15.7 ± 2.5 mV Macrophage CM Coextrusion Cao et al. (2020)
PLGA NP 140–150 nm −14 mV Dendritic CM Coextrusion Cheng et al. (2020)
Silica NP 150 ± 11 nm −10.8 ± 0.2 mV Tumor EM Passive loading Yong et al. (2019)
RNA–protein coacervates ∼2 µm +4–30 mV Fatty acid Electrostatic deposition Dora Tang et al. (2014)
Polydopamine-coated PLGA MP 3.3 ± 1.8 µm - Serum-derived EM Chemical conjugation You et al. (2020)
PLGA MP 3–25 µm −11.8 to −2.4 mV Protamine Double emulsion evaporation Martínez Gómez et al. (2008)
Tannic acid-doped calcium carbonate particles ∼5 µm - 10 different proteins with different sizes and isoelectric points Adsorption Shi et al. (2019)
DEAE-dextran/dsDNA coacervate droplets 5.4 ± 1.9 µm +15.1 ± 1.7 mV RBCM Pickering emulsion Liu et al. (2020)
Dextran-in-PEG droplets ∼7 µm - Anionic lipid vesicles Pickering emulsion Dewey et al. (2014)
Lipid MP 5–38 µm - Chitosan Emulsion evaporation Scalia et al. (2015)
PLGA MP ∼200 µm - Alginate Coaxial electrospray Choi et al. (2010)
Starch MP 300–750 µm - Chitosan Adsorption Song et al. (2021)