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. 2022 Oct 26;379:e072046. doi: 10.1136/bmj-2022-072046

Table 7.

Interaction between groups that received preconception or pregnancy interventions compared with those that did not receive these interventions

Primary outcome No preconception intervention Preconception intervention Measure of interaction (95% CI)
% or mean (SD) IRR or MD (95% CI) % or mean (SD) IRR or MD (95% CI)
Low birth weight
No pregnancy intervention 28.6 1.00 21.9 0.78 (0.67 to 0.91); P=0.001 1.20 (0.97 to 1.48); P=0.10
Pregnancy intervention 24.6 0.82 (0.69 to 0.96); P=0.01 23.4 0.76 (0.65 to 0.88); P<0.001
Preterm birth
No pregnancy intervention 14.8 1.00 12.6 0.88 (0.71 to 1.09); P=0.24 1.52 (1.11 to 2.08); P=0.01
Pregnancy intervention 10.2 0.69 (0.54 to 0.89); P=0.005 13.3 0.91 (0.73 to 1.14); P=0.41
Small for gestational age
No pregnancy intervention 37.2 1.00 29.9 0.81 (0.72 to 0.91); P=0.001 1.17 (0.98 to 1.40); P=0.09
Pregnancy intervention 28.7 0.76 (0.66 to 0.87); P<0.001 27.9 0.71 (0.62 to 0.81); P<0.001
Birth weight (g)
No pregnancy intervention 2744 (459) 0.00 2816 (449) 65 (26 to 103); P=0.001 −47 (−101 to −7); P=0.09
Pregnancy intervention 2785 (439) 60 (17 to 103); P=0.007 2797 (438) 77 (36 to 119); P<0.001
Birth length (cm)
No pregnancy intervention 47.9 (2.2) 0.00 48.19 (2.07) 0.29 (0.11 to 0.47); P=0.002 −0.23 (−0.48 to 0.02); P=0.08
Pregnancy intervention 48.0 (2.1) 0.21 (−0.01 to 0.41); P=0.05 47.98 (2.06) 0.23 (0.02 to 0.44); P=0.03
Length-for-age z score at 24 months
No pregnancy intervention −1.0 (1.2) 0.00 −1.00 (1.13) 0.01 (−0.15 to 0.17); P=0.90 0.12 (−0.10 to 0.34); P=0.28
Pregnancy intervention −0.7 (1.1) 0.31 (0.14 to 0.48); P<0.001 −0.58 (1.17) 0.46 (0.30 to 0.63); P<0.001
Stunting at 24 months
No pregnancy intervention 18.8 1.00 19.4 0.98 (0.73 to 1.32); P=0.91 0.92 (0.56 to 1.54); P=0.76
Pregnancy intervention 10.9 0.56 (0.37 to 0.84); P=0.005 10.4 0.49 (0.34 to 0.70); P<0.001

CI=confidence interval; IRR=incidence rate ratio; MD=mean difference; SD=standard deviation.