Table 7.
Primary outcome | No preconception intervention | Preconception intervention | Measure of interaction (95% CI) | |||
---|---|---|---|---|---|---|
% or mean (SD) | IRR or MD (95% CI) | % or mean (SD) | IRR or MD (95% CI) | |||
Low birth weight | ||||||
No pregnancy intervention | 28.6 | 1.00 | 21.9 | 0.78 (0.67 to 0.91); P=0.001 | 1.20 (0.97 to 1.48); P=0.10 | |
Pregnancy intervention | 24.6 | 0.82 (0.69 to 0.96); P=0.01 | 23.4 | 0.76 (0.65 to 0.88); P<0.001 | ||
Preterm birth | ||||||
No pregnancy intervention | 14.8 | 1.00 | 12.6 | 0.88 (0.71 to 1.09); P=0.24 | 1.52 (1.11 to 2.08); P=0.01 | |
Pregnancy intervention | 10.2 | 0.69 (0.54 to 0.89); P=0.005 | 13.3 | 0.91 (0.73 to 1.14); P=0.41 | ||
Small for gestational age | ||||||
No pregnancy intervention | 37.2 | 1.00 | 29.9 | 0.81 (0.72 to 0.91); P=0.001 | 1.17 (0.98 to 1.40); P=0.09 | |
Pregnancy intervention | 28.7 | 0.76 (0.66 to 0.87); P<0.001 | 27.9 | 0.71 (0.62 to 0.81); P<0.001 | ||
Birth weight (g) | ||||||
No pregnancy intervention | 2744 (459) | 0.00 | 2816 (449) | 65 (26 to 103); P=0.001 | −47 (−101 to −7); P=0.09 | |
Pregnancy intervention | 2785 (439) | 60 (17 to 103); P=0.007 | 2797 (438) | 77 (36 to 119); P<0.001 | ||
Birth length (cm) | ||||||
No pregnancy intervention | 47.9 (2.2) | 0.00 | 48.19 (2.07) | 0.29 (0.11 to 0.47); P=0.002 | −0.23 (−0.48 to 0.02); P=0.08 | |
Pregnancy intervention | 48.0 (2.1) | 0.21 (−0.01 to 0.41); P=0.05 | 47.98 (2.06) | 0.23 (0.02 to 0.44); P=0.03 | ||
Length-for-age z score at 24 months | ||||||
No pregnancy intervention | −1.0 (1.2) | 0.00 | −1.00 (1.13) | 0.01 (−0.15 to 0.17); P=0.90 | 0.12 (−0.10 to 0.34); P=0.28 | |
Pregnancy intervention | −0.7 (1.1) | 0.31 (0.14 to 0.48); P<0.001 | −0.58 (1.17) | 0.46 (0.30 to 0.63); P<0.001 | ||
Stunting at 24 months | ||||||
No pregnancy intervention | 18.8 | 1.00 | 19.4 | 0.98 (0.73 to 1.32); P=0.91 | 0.92 (0.56 to 1.54); P=0.76 | |
Pregnancy intervention | 10.9 | 0.56 (0.37 to 0.84); P=0.005 | 10.4 | 0.49 (0.34 to 0.70); P<0.001 |
CI=confidence interval; IRR=incidence rate ratio; MD=mean difference; SD=standard deviation.