Fig. 1.

CK improves glucose homeostasis partially through enhancing the GLP-1 secretion in db/db mice. 4-Week-old male db/db mice were treated with CK, with wild-type C57BL/6 J mice used as controls. Body weight (A), Body weight gain (B), liver weight and liver/body ratio (C) were observed. Results of the oral glucose tolerance test (OGTT) performed at the end of the study (D), and the calculated average changes from baseline in the area under the curve (AUC) (E). Insulin levels (F) after overnight fasting following CK treatment, and homeostasis model assessment of insulin resistance was calculated as HOMA-IR (G). Serum GLP-1 levels (H). Data are presented as the mean ± s.e.m., n = 6 per group. ∗P < 0.05, ∗∗P < 0.01 versus the db/db group.