Fig. 5.

CK promotes more cells converting into more GLP-1 producing. Gene expression of cell type markers of secretory and absorptive cells (A). Gcg⁺ cells in the ileum of control, db/db, and CK-treated mice (B). Nuclei labeled by DAPI. Scale bars, 25 μm. White arrows indicate positive Gcg staining. Percentage of Gcg-positive cells (C). Gcg expression in mouse ileum (D). Gene expression of intestinal cell type markers and transcription factors directing L-cell development (F). Data are presented as the mean ± s.e.m., n = 3 per group. ∗P < 0.05, ∗∗P < 0.01 versus the db/db group.