TABLE 1.

Definitions of circadian rest activity rhythm (CRAR) indices.

	Definition
Cosinor indices
Amplitude	Difference between the minimum and maximum activity value
Mesor	Average activity over 24 h
Acrophase	Time of maximum activity counts over 24 h
Non-parametric indices
Relative amplitude (RA)	Metric of rhythm strength; normalized difference between most active 10 h and least active 5 h
Interdaily stability (IS)	Stability of activity profiles over days
Intradaily variability (IV)	Fragmentation of the rhythm relative to its 24-h amplitude
L5 time	Midpoint of an individual’s L5 interval
M10 time	Midpoint of an individual’s M10 interval