TABLE 10.

Associations of circadian metrics with attention, estimated beta (95% CI).

	Model 1		Model 2
	Baseline cross-sectional effect	Effect on cognitive change	Baseline cross-sectional effect	Effect on cognitive change
Cosinor metrics
Amplitude	–	–	–	–
Mesor	–	–	–	–
Acrophase	−0.02 (−0.09, 0.04)	0.003 (−0.01, 0.02)	−0.02 (−0.09, 0.04)	0.004 (−0.01, 0.02)
Non-parametric
RA	0.02 (−0.04, 0.08)	0.002 (−0.01, 0.02)	0.01 (−0.06, 0.07)	0.001 (−0.01, 0.02)
IS	0.05† (−0.01, 0.11)	−0.003 (−0.02, 0.01)	0.05 (−0.02, 0.11)	−0.01 (−0.02, 0.01)
IV	–	–	–	–
L5 time	−0.004 (−0.06, 0.05)	†−0.01 (−0.02, 0.001)	0.003 (−0.05, 0.06)	−0.01† (−0.02, 0.002)
M10 time	−0.01 (−0.07, 0.05)	0.01 (−0.01, 0.02)	−0.01 (−0.07, 0.05)	0.01 (−0.01, 0.02)

– = significant interaction, main effect not reported (see tables below). Model 1 adjusted for baseline age, sex, race, years of education, time, baseline age*time, sex*time, race*time, and years of education*time. Model 2 adjusted for Model 1 covariates, in addition to baseline BMI, sleep medication use, APOE e4 status, depression symptoms (minus the sleep item), cardiovascular disease risk, smoking status, BMI*time, cardiovascular disease risk*time, smoking status*time, sleep medication*time, APOE e4 status*time, and depression symptoms (minus the sleep item)*time. ^†p < 0.10.