Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 12;12:999643. doi: 10.3389/fonc.2022.999643

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhou, Lei, Tian, Guo, Chen, Qiu, Wu, Li and Chang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The role of metabolism on cervical cancer radioresistance. Glucose is transported into cells through GLUT1 for glycolysis and produces a large amount of lactic acid, enhancing cervical cancer radioresistance. Glucose in cells also produces GSH through PPP pathway. The antioxidant GSH weakens DSB after RT, resulting in radioresistance of cervical cancer cells. High expression of COX-2 in lipid metabolism and Glutamine in amino acid metabolism also contribute to cervical cancer radioresistance. GLUT1, glucose transporter 1; PPP, pentose phosphate pathway; ROS, reactive oxygen species; HIF-1, hypoxia-inducible factor 1; GSSG, oxidized glutathione; GSH, glutathione; RT, radiotherapy.