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. 2022 Oct 12;12:1008484. doi: 10.3389/fonc.2022.1008484

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Copyright © 2022 Lazcano, Barreto, Salazar, Carapeto, Traweek, Leung, Gite, Mehta, Ingram, Wani, Vu, Parra, Lu, Zhou, Witt, Cope, Thirasastr, Lin, Scally, Conley, Ratan, Livingston, Zarzour, Ludwig, Araujo, Ravi, Patel, Benjamin, Wargo, Wistuba, Somaiah, Roland, Keung, Solis, Wang, Lazar and Nassif

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative Immunohistochemistry (IHC) Images of Tumor-Associated Immune Cells and Immune Checkpoints in UPS by Immune Clusters. On the left in blue square brackets, IHC images of UPS tumors expressing low cell density of CD3, CD8, PD1, CD163, and tumor cells negative for CD39 and CD73, which are characteristic of the Immune Low cluster samples. On the middle column in yellow square brackets IHC images of UPS tumors with moderate density of CD3, CD8 and PD1, and high density of macrophages expressing CD163, and tumor cells positive for CD39 and CD73, which is characteristic of the Immune Intermediate cluster. On the right column in red square brackets, IHC images of UPS tumors with high cell density of all the biomarkers shown, which are representative of the Immune High cluster, IHC images are at 400x magnification.