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. 2022 Oct 12;13:1022403. doi: 10.3389/fmicb.2022.1022403

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Copyright © 2022 Pan, Zheng, Zheng, Shi, Ning, Zhang, Xie, Xiang and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HQLHS regulated the intestinal flora disorder caused by type 2 diabetes. (A) Principal co-ordinates analysis (PCoA) of the cecal content microbiota. (B) Heat map statistics of significant difference genus. (C) Analysis of differences in the microbial taxa shown by [linear discriminant analysis (LDA; LEfSe) coupled with effect size measurements] between the DM group and the DM-HQ group (log10 LDA > 2.0). (D) Visualization of the correlation network between glycolipid parameters and dominant genus in the DM-HQ group based on Spearman’s rank correlation coefficient. Data are expressed as mean ± SEM. One-way ANOVA was used to analyze statistical differences; Compare to NC: *p < 0.05; **p < 0.01; and ***p < 0.001; Compare to DM: ^#p < 0.05; ^##p < 0.01; and ^###p < 0.001.