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. 2022 Oct 11;13:1027403. doi: 10.3389/fimmu.2022.1027403

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Copyright © 2022 Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representations of HDAC1 related mechanism in allergic diseases. Allergic disease patients have an epithelial barrier suffering from allergen stimulation. Exposure to allergens activate dendritic cell and increase HDAC1 expression, leading to significantly increase Th2 cytokine levels, decrease Th1/Th17 cells and anti-inflammatory cytokine IL-10, and Trek-1 expression.