TABLE 9.
Concentrations of free HIV-1 p24 antigen measured by the improved immunoassay and HIV-1 virion-associated p24 antigen calculated from HIV-1 RNA copies measured by RT-PCR (panels 10, 14, 16, 17, 18, and 19)
| HIV-1 seroconversion serum panel no. | Days after initial blood collection | HIV-1 p24 antigen measured by the improved immunoassay
|
HIV-1 RNA measured by RT-PCR
|
Ratio (F/A) | |||
|---|---|---|---|---|---|---|---|
| Cutoff index | Amt (pg/ml) (F) | Cut-off index | Copies/ml | Virion-associated p24 antigen (pg/ml) (A) | |||
| 10 (SV-0241) | 0 | 29 | 0.96 | 110 | 43,000 | 1.0 | 0.93 |
| 6 | 5,800 | 190 | 7,500 | 3,000,000 | 72 | 2.7 | |
| 8 | 2,400 | 79 | 2,500 | 1,000,000 | 24 | 3.3 | |
| 14 | 150 | 5.1 | 300 | 120,000 | 2.9 | 1.8 | |
| 16 | 48 | 1.6 | 88 | 35,000 | 0.84 | 1.9 | |
| 21 | 1.8 | 0.06 | 9.8 | 3,900 | 0.09 | 0.66 | |
| 23 | 0.70 | 3.8 | 1,500 | 0.04 | |||
| 14 (SV-0211) | 0 | 1,000 | 34 | 375 | 150,000 | 3.6 | 9.4 |
| 2 | 6,600 | 220 | 1,700 | 660,000 | 16 | 14 | |
| 13 | 3,100 | 100 | 3,300 | 1,300,000 | 31 | 3.4 | |
| 15 | 1,200 | 41 | 950 | 380,000 | 9.1 | 4.5 | |
| 22 | 85 | 2.8 | 22 | 8,800 | 0.21 | 13 | |
| 16 (panel X) | 0 | 0.23 | <0.1 | ||||
| 2 | 0.22 | <0.1 | |||||
| 8 | 0.26 | <0.1 | |||||
| 10 | 0.21 | <0.1 | |||||
| 26 | 2,600 | 88 | 340 | 130,000 | 3.2 | 27 | |
| 33 | 590 | 20 | 80 | 32,000 | 0.77 | 26 | |
| 35 | 100 | 3.4 | 30 | 12,000 | 0.28 | 12 | |
| 40 | 120 | 3.9 | 13 | 5,100 | 0.12 | 32 | |
| 17 (panel Y) | 0 | 0.44 | <0.1 | ||||
| 10 | 0.21 | <0.1 | |||||
| 18 | 0.20 | <0.1 | |||||
| 22 | 0.19 | <0.1 | |||||
| 44 | 350 | 12 | 390 | 140,000 | 3.8 | 3.1 | |
| 49 | 160 | 5.4 | 430 | 170,000 | 4.1 | 1.3 | |
| 18 (panel AR) | 0 | 0.40 | <0.1 | ||||
| 2 | 0.29 | <0.1 | |||||
| 9 | 9.1 | 0.30 | 25 | 9,800 | 0.24 | 1.3 | |
| 14 | 780 | 26 | 2,200 | 880,000 | 21 | 1.2 | |
| 19 (panel 6240) | 0 | 0.20 | <0.1 | ||||
| 2 | 0.17 | <0.1 | |||||
| 7 | 0.11 | <0.1 | |||||
| 9 | 0.13 | <0.1 | |||||
| 14 | 0.11 | <0.1 | |||||
| 16 | 0.26 | <0.1 | |||||
| 21 | 25 | 0.82 | 46 | 19,000 | 0.45 | 1.8 | |
| 23 | 310 | 10 | 380 | 150,000 | 3.6 | 2.9 | |
| 28 | 5,200 | 170 | 2,500 | 1,000,000 | 24 | 7.2 | |
| 30 | 7,900 | 260 | 2,500 | 990,000 | 24 | 11 | |
| 36 | 1,100 | 36 | 720 | 290,000 | 6.9 | 5.1 | |
| 45 | 180 | 6.1 | 64 | 25,000 | 0.61 | 10 | |
| 53 | 99 | 3.3 | 47 | 19,000 | 0.45 | 7.3 | |