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. 2022 Sep 27;298(11):102536. doi: 10.1016/j.jbc.2022.102536

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

A rat model of obstructive sleep apnea using intermittent hypoxia leads to H3K9me3 demethylation and increased HIF1a expression in the liver.A, intermittent hypoxia profile for fraction of inspired oxygen (FiO₂). During each hypoxic period, the FiO₂ was reduced from room air levels to 6% O₂ v/v for 1 min, followed by a reoxygenation to room air (21% O₂ v/v) for 2.5 min. This protocol was repeated for 8 h. B, Western blot of HIF-1α and H3K9me3 levels. Histone H3 is used as a loading control. C, densitometry of H3K9me3:Histone H3. D, Hif1a mRNA levels. E, densitometry of HIF-1α:Histone H3. Values are normalized to normoxia (Log2 scale). Results are the mean ± SD of n = 6 rats. ∗p < 0.05.