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ORR in KRAS G12C NSCLC by STK11 and KEAP1 mutation status from single arm phase II studies of sotorasib (CodeBreaK100 [94]) and adagrasib (KRYSTAL-1 [100])
| Overall (%) | STK11mt, KEAP1wt (%) | STK11mt, KEAP1mt (%) | STK11wt, KEAP1mt (%) | |
|---|---|---|---|---|
| Sotorasib 920 mg daily | 37.1 | 50 | 23 | 14 |
| Adagrasib 600 mg bid | 42.9 | 44.0 | 35.7 | 14.3 |
