Table 2.
Effect of COMT haplotypes on symptoms at the Chronic Fatigue Syndrome symptom list (CSL), pain thresholds, and conditioned pain modulation in both healthy controls (HC) and patients with Chronic Fatigue Syndrome and Fibromyalgia (CFS/FM). Data is expressed as estimated adjusted mean (standard error). Mean difference and p-values refer to the difference between the first and the last category. CPT: cold pain thresholds; HPT: heat pain thresholds; C-CPM: conditioned pain modulation to cold stimuli; H-CPM: conditioned pain modulation to heat stimuli
| Healthy controls | Patients with CFS/FM | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
COMT High activity |
COMT High-intermediate activity |
COMT Intermediate activity |
COMT intermediate-low activity |
COMT High activity |
COMT High-intermediate activity |
COMT Intermediate activity |
COMT intermediate-low activity |
Mean diff. (95% C.I.) |
p | |
| CSL Total |
18.78 (8.85) |
22.54 (5.55) |
28.86 (8.59) |
63.55 (13.02) |
91.83 (10.73) |
95.59 (5.08) |
101.91 (8.93) |
136.60 (11.95) |
-44.771 (-87.89; -1.65) |
0.014* |
| CPT (°C) |
2.10 (1.51) |
5.24 (1.15) |
4.49 (1.42) |
11.36 (2.15) |
5.47 (1.61) |
8.61 (0.95) |
7.83 (1.48) |
14.74 (2.38) |
-9.263 (-16.197; -2.33) | 0.006* |
| HPT (°C) |
47.55 (0.95) |
47.19 (0.72) |
47.73 (0.89) |
46.45 (1.35) |
45.80 (1.01) |
45.44 (0.60) |
45.97 (94) |
44.69 (1.50) |
1.108 (-3.26; 5.47) | 0.825 |
| C-CPM (°C) |
2.19 (0.56) |
2.43 (0.41) |
2.05 (0.50) |
4.99 (0.77) |
1.97 (0.57) |
2.22 (0.34) |
1.84 (0.52) |
4.78 (3.02) |
-2.804 (-5.39; − 0.21) | 0.011* |
| H-CPM (°C) |
1.23 (0.40) |
1.14 (0.30) |
1.17 (0.37) |
2.10 (0.56) |
0.89 (0.42) |
0.81 (0.25) |
0.84 (0.37) |
1.76 (0.62) |
− 0.872 (-2.68; 0.93) | 0.418 |