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. 2022 Oct 11;11(10):2012. doi: 10.3390/antiox11102012

Figure 4.

Figure 4

The regulation of melatonin on the GSH, GSSG, and GSH/GSSG ratio in the lung tissue of LPS-induced ALI mice and in the LPS-induced DCs. (A–C) In the ALI model, lung tissue samples were homogenized at 6 h after LPS challenge. (D–F) DCs were stimulated with different concentrations of melatonin in the presence or absence of LPS (100 ng/mL) for 24 h, then the DCs were harvested and lysed. The GSH content (A,D), GSSG content (B,E), and the ratio of GSH/GSSG (C,F) in the lung tissue and DC lysate were tested according to Materials and Methods. The data shown represent the means ± SD from one of three independent experiments. Statistical significance is determined using variance (ANOVA). * p < 0.05, ** p < 0.01.