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. 2022 Sep 21;10(10):2356. doi: 10.3390/biomedicines10102356

Table 2.

Hypomagnesemia-induced arrhythmogenic mechanisms.

Hypomagnesemia-Dependent Arrhythmogenic Mechanisms
  • inadequate effect of low Mg2+ concentrations against calcium in the AV node and ventricular myocardium

  • low magnesium causes malfunction of Na+/K+-ATPase, consequently creating a less negative resting membrane potential by decreasing the concentration of intracellular K+ and increasing intracellular Na+

  • hypomagnesemia-dependent hypokalaemia and hypocalcemia

  • direct effect of magnesium on preventing calcium overload in the myocite

  • PAF- related inflammatory cardiac response linked to arrhythmias

  • disturbance of the action-potential