Table 1.
Baseline characteristics of patients included in the study.
| Parameter | All Patients Studied N. 18 | MDRO/XDRO Infection | Colonisation without Infection |
|---|---|---|---|
| N. 10 | N. 6 | ||
| Age, years | 54 [45–69] | 62 [43–70] | 51 [43–61] |
| Sex M/F | 10 (55.6)/8 (44.4) | 3 (30)/7 (70) | 5 (83.3)/1 (16.7) |
| Previous hospitalisation | 12 (75) | 7 (70) | 3 (50) |
| Neuromuscular disorder | |||
| Amyotrophic lateral sclerosis | 14 (77.8) | 8 (80) | 4 (66.7) |
| Duchenne muscular dystrophy | 1 (5.55) | 1 (10) | - |
| Steinert myotonic dystrophy | 1 (5.55) | 1 (10) | - |
| Spinocerebellar ataxia type 2 | 1 (5.55) | - | 1 (16.7) |
| Dysmetabolic axonal sensory-motor polyneuropathy | 1 (5.55) | - | 1 (16.7) |
| Comorbidities | |||
| Congestive heart failure | 2 (11.1) | 1 (10) | 0 |
| Chronic kidney disease | 2 (11.1) | 1 (10) | 0 |
| Diabetes mellitus | 2 (11.1) | 1 (10) | 1 (16.7) |
| Chronic pulmonary disease | 1 (5.55) | 0 | 1 (16.7) |
| Chronic liver disease | 1 (5.55) | 1 (10) | 0 |
| Peripheral vascular disease | 1 (5.55) | 1 (10) | 0 |
| Malignant neoplasia | 2 (11.1) | 2 (20) | 0 |
| Cerebrovascular accident | 2 (11.1) | 1 (10) | 1 (16.7) |
| Hemiplegia | 15 (83.3) | 8 (80) | 5 (83.3) |
| Charlson comorbidity index | 3.5 [2–5.2] | 4.5 [2–6] | 3 [2–4.7] |
| Invasive procedures/devices | 18 (100) | 10 (100) | 6 (100) |
| Parenteral nutrition | 14 (77.8) | 8 (80) | 4 (66.7) |
| Peripherally inserted central catheter | 9 (50) | 5 (50) | 2 (33.3) |
| Midline | 1 (5.5) | 1 (10) | 0 |
| Central venous catheter | 3 (16.7) | 2 (20) | 0 |
| Peripheral venous catheter | 9 (50) | 6 (60) | 2 (33.3) |
| Tracheostomy | 13 (72.2) | 7 (70) | 4 (66.7) |
| Hematochemical data | |||
| Creatinine baseline, mg/dl | 0.2 [0.15–0.45] | 0.2 [0.15–0.45] | 0.4 [0.4–0.4] |
| Creatinine onset 1 *, mg/dl | 0.2 [0.2–0.5] | 0.2 [0.1–0.45] | 0.3 [0.2–1] |
| Creatinine onset 2 **, mg/dl | 0.2 [0.1–0.3] | 0.15 [0.1–0.45] | |
| Bilirubin baseline, mg/dl | 0.6 [0.5–1.8] | 0.67 [0.48–2.41] | 0.62 [0.62–0.62] |
| Bilirubin onset 1 *, mg/dl | 0.5 [0.4–0.7] | 0.8 [0.3–2.1] | 0.57 [0.46–0.68] |
| Bilirubin onset 2 **, mg/dl | 0.6 [0.4– -] | 0.49 [0.49–0.49] | |
| WBC > 15.000/mmc during hospital stay | 6 (33.3) | 4 [40] | 0 |
| PLT < 10.000/mmc during hospital stay | 0 | 0 | 0 |
| Albumin < 3.5 g/dl during hospital stay | 6 (33.3) | 5 (50) | 0 |
| Outcome | |||
| Survived | 17 (94.4) | 10 (100) | 5 (83.3) |
| Deceased | 1 (5.6) | 0 | 1 (16.7) |
Data are N (%) or median [IQR]. * onset of first pathogen, ** onset of second pathogen.