FIG. 3.

Levels of IL-18 in patients with CNS complications due to M. pneumoniae infection. Early-onset encephalitis is defined as a CNS disease onset of ≤7 days from the onset of fever; late-onset encephalitis is defined as a CNS disease onset of ≥8 days (22). ●, with pneumonia; ○, without pneumonia. A solid line within the same kind of samples and a dotted line between serum and CSF samples indicate that the samples were from the same individual. The broken lines at 12.5 and 260 pg/ml denote a minimal significant level of detection and the normal upper limit of IL-18 in serum, respectively.