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. 2022 Oct 12;13:1002616. doi: 10.3389/fimmu.2022.1002616

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Copyright © 2022 Lv, Zhang, Zhao, Yang, Zou, Zhao, Li, Sun, Lin and Jin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulated pro-inflammatory cytokines increase ASFV infection in PAMs. (A, B) Overexpression of HA-tagged C1QTNF3 proteins was detected using western blot analysis. (C) C1QTNF3 overexpression in PAMs increases ASFV replication as detected using the HAD assay. The mRNA levels of (D) IL-1β, (E) IL-8, and (F) IL-6 upon C1QTNF3 overexpression in PAMs infected with ASFV. The GAPDH gene was used as the internal control for normalization. The 2^-ΔΔCt method was used to analyze the results of qPCR. The protein levels of (G) IL-8, (H) IL-6, and (I) IL-1β upon C1QTNF3 overexpression in PAMs infected with ASFV p <0.05 (*), p < 0.01 (**).