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. 2022 Sep 30;10(10):2443. doi: 10.3390/biomedicines10102443

Figure 3.

Figure 3

Studies of cellular fitness on VCP–mutant and control fibroblasts. (A) Decrease of proliferation in patient–derived fibroblasts compared to controls under basal conditions. A significant effect of arimoclomol treatment on proliferation of patient–derived cells was observed. Basal fitness levels in control and VCP–patient fibroblasts are displayed on the left and fitness levels after treatment with arimoclomol are displayed on the right for each group, respectively. (B) Arimoclomol treatment reduced cytotoxicity in patient and control fibroblasts with a higher extend in patient derived cells.