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. 2022 Sep 21;11(10):1859. doi: 10.3390/antiox11101859

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Brusatol synergized with cisplatin (CDDP) in killing EAC cells. (A) Bright images of cells treated with Brusatol, CDDP, or both for 3 days. (B) Clonogenic survival assay shows that combination treatment of Brusatol and CDDP killed a significantly more tumor cells. (C,D) The CellTiter Glo cell viability assay using Brusatol, CDDP, and both in FLO1 (C) and OE33 (D) cells. The IC50 of CDDP and Brusatol were plotted using Prism software. Data show that the combination treatment led to a significant 50% drop in CDDP IC50. (E,F) Synergy analysis using online synergyfinder tool (http://synergyfinder.org/, accessed on 10 May 2022) in FLO1 (E) and OE33 cells (F), demonstrating that a significant synergy effect occurred when applying Brusatol and CDDP. * p < 0.05; ** p < 0.01; ns, not significance.